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3,232 sig. ATXN7L1. 222255 ataxin 644165 breakpoint cluster region pseudo. 22. 25028882.

Mirna 17-92 cluster

Our deletion analysis of the 2010-07-01 In the current study, the expression profiles of cellular miRNAs in infected and non-infected cells were compared by microarray analysis and we observed that miR-17-92, one of the best characterized polycistronic miRNA clusters (Mendell, 2008; Olive et al., 2013a), was substantially reduced upon EV71 infection and overexpression of this cluster inhibited viral replication. 2018-04-18 Therefore, miRNA 17–92 cluster may be involved in Y79 cell invasive property. Earlier, reports have shown that miR 17–92 cluster inhibits PTEN expression in human hepatocellular cancer and mouse lymphoproliferative disorders, and resulted in increased tumor … Overexpression of the miR-17-92 cluster in MLL-rearranged leukemias. (A) Expression profiling of the miRNA cluster in 72 acute leukemic and normal samples as detected by the bead-based method. Micro-RNAs (miRNAs) have emerged as novel gene expression regulators.

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MYB in blast cells from 2 Ph+ leukemia patients correlated positively. 28 May 2014 The polycistronic miR-17-92 cluster is the first microRNA cluster shown to play a role in tumorigenesis. It has two other paralogs in the human 14 Jun 2017 DELETION OF CARDIAC miR-17-92 CLUSTER INCREASES ISCHEMIC/ REPERFUSION.

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Oncogenic Mir-92 has been mapped to the human genome as part of a larger cluster at This long precursor sequence is a component of the mir-17-92 cluster which including an oncogenic miR-17-92 cluster and oncosuppressive miR-143-145 cluster, and snoRNAs in synchronous CRC. Differential miRNA rather than Nyliga expressionsprofileringsstudier rapporterade mikroRNA (miRNAs) (och i synnerhet miR-17-92-kluster) som användbara verktyg för differentiering av The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-beta Pathway in Neuroblastoma. Forskningsoutput: Tidskriftsbidrag › Artikel i The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-beta Pathway in Neuroblastoma. This page in English. Författare Recent studies have revealed the importance of multiple microRNAs (miRNAs) in promoting tumorigenesis, among which mir-17-92/Oncomir-1 exhibits potent 2. montering av miRNA-moduler i ett Polycistronic transgena kluster. Beredning av transgen byggnadsställning baserad på miR-17-92 Cluster Meng, Wen-Jian (författare); MicroRNA Expression Profile Reveals miR-17-92 and miR-143-145 Cluster in Synchronous Colorectal Cancer [Elektronisk resurs] 2017 — kunnat påvisa också en mer än fördubblad expression av miR-17/92 Rigoutsos I. The miR-17/92 cluster: a comprehensive update on its.

Sid 17 (92) Finska kluster har möjliggjort ett studiebesök i Finland. Nämndmål: 4. Uppsala Slavic Papers 17), 92 pp.
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2013-11-11 The median survival of patients with mantle cell lymphoma (MCL) ranges from 3 to 5 years with current chemotherapeutic regimens. A common secondary genomic alteration detected in MCL is chromosome 13q31-q32 gain/amplification, which targets a microRNA (miRNA) cluster, miR-17∼92… MiR-17-92 cluster is an oncogenic miRNA cluster that is implicated in several cancers, although its role in hepatocarcinogenesis has not been clearly defined. In this study, we show that the miR-17-92 cluster is highly expressed in human hepatocellular carcinoma (HCC) tissues compared to the non-tumorous liver tissues by RT-PCR and in situ hybridization analyses. The mircoRNA-17-92 cluster encoded by the miR-17-92 host gene is first found in malignant B-cell lymphoma.
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Crossref Medline Google Scholar; 16. Zhang Y, Ueno Y, Liu XS, Buller B, Wang X, Chopp M, et al.. The MicroRNA-17-92 cluster enhances axonal outgrowth in embryonic cortical The miR-17-92 cluster was among the first miRs that were linked to tumor angiogenesis. The miR-17-92 cluster is a typical example of a polycistronic miR cluster encoding the miRs miR-17, miR-18a, miR-19a/b, miR-20a, and miR-92a, which are highly expressed in several tumors.

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Recent researches showed that the miR-17-92 cluster also plays novel functions in the endocrine The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia. Whereas miR-92a was recently identified as negative regulator of angiogenesis, the specific functions of the other members of the cluster are less clear. A polycistronic microRNA cluster, miR-17–92, is overexpressed in human lung cancers and enhances cell proliferation Cancer Res , 65 ( 2005 ) , pp. 9628 - 9632 View Record in Scopus Google Scholar The miR-17-92 cluster is a typical highly conserved polycistronic miRNA cluster, which is located in the human chromosome 13 open reading frame 25 (C13orf25), encoding six mature miRNAs, including miR-17, miR-18a, miR-19a, miR-19b, miR-20a and miR-92a (10).